The immigrations that the Ottoman Empire was exposed to in the 19th century launched a new social mobility in Ottoman territories after the Crimean War (1853-1856). Especially the immigrations in 1864 starting with the great emigration of the Circassians after the Russian conquest faced the Ottoman Empire a huge and massive migration movements that could not be compared with the previous immigrations. In this immigration process, southern Black Sea ports, Trabzon and Samsun served as main entry ports for immigrants in the Ottoman territories. However, these immigrations led to serious issues to these port cities. The Ottoman government took some series measures to prevent both the immigrants and the indigenous people from the problems caused by the migration. This process, managed basically by the Refugee Commission, was an issue for international community in terms of the political and social consequences of the immigration. In this context, the Quarantine Council that had an international character closely followed this process. This study aims to investigate the mission of Dr. Barozzi sent by the Sublime Porte, as a member of the Quarantine Council, his measures and his act